Phosphine Ligands: Small Reactions, Big Impact
As the industry leader in phosphine ligands and catalysts for homogeneous catalysis, Syensqo offers a range of phosphorus compounds used in a breadth of applications and markets. Our scalable phosphorus chemistry meets the unique requirements of reactions that are crucial to several manufacturing processes across markets and applications, including petrochemicals, life sciences, flavors and fragrances, agrochemicals, fine chemicals, and plastics and other polymers.
Homogeneous catalysis is an efficient alternative to its heterogeneous counterpart, and enables access to certain molecules that are not accessible through heterogeneous catalysis. Our high-performance phosphine ligands provide endless customization opportunities for catalytic processes. Phosphorus chemistry offers substantial diversity of structure, tunability and thermal stability, which leads to its use in many essential industries and an abundance of applications.
A majority of Syensqo’s phosphorus technologies are available in liquid or solution form, which facilitates ease of handling and safe product stewardship. Solids are available if preferred. Produced via industry-recognized manufacturing processes, our phosphine ligands and catalysts can be manufactured at any scale. Syensqo offers expertise and manufacturing wherewithal at any phase of the value chain, but specializes in developing ligand solutions from the initial R&D stage all the way to industrial-scale production and distribution.
Many of our featured products serve as building blocks for innovative phosphine ligands and can be tailored for specific industrial applications. To that end, Syensqo works closely with our partners from their earliest stages of development under the appropriate agreements to develop application-specific products.
We’re more than a raw material supplier to our customers. When it comes to the development of phosphine ligands and catalysts, Syensqo is a partner to companies looking for scalable solutions that measurably improve their most critical reactions.
Phosphine Ligands for Petrochemicals
Petrochemical catalysis is critical to basic building blocks in chemistry. Syensqo’s phosphine ligands play an enabling role within the industry. Our phosphine ligands and catalysts facilitate reactions such as ethylene dimerization, olefin oligomerization, hydroformylation, hydrogenation, metathesis and more to drive petrochemical innovation. Working directly with refiners or catalyst producers, Syensqo provides scalable solutions, transitioning newly developed products and custom solutions from the lab to industrial-scale production.
Key Products:
- RhodaPhos® NiCat Dichlorobis(tributylphosphine)nickel(II)
- CYTOP® 282T 9-phosphabicylononane
- CYTOP® 341 (triisobutylphosphine)
- CYTOP® 366 tricyclohexylphosphine
Phosphine Ligands for Life Sciences
Phosphine ligands for pharmaceutical catalysis continue to drive drug substance synthesis and treatment technologies. Syensqo’s range of phosphorus derivatives for pharmaceutical applications enables substantial improvements in quality control and customization. We work closely with catalyst manufacturers and pharmaceutical licensees in the life sciences industry to develop solutions that meet industry safety requirements. Homogeneous catalytic reactions in pharmaceutical applications that benefit from phosphine ligands include metathesis, hydroamination, cross-coupling and chiral hydrogenation reactions.
Key Products:
- CYTOP® 242 di-tert-butylphosphine
- CYTOP® 208 tris(3-hydroxypropyl)phosphine
- CYTOP® 340 tributylphosphine
- RhodaPhos® CP100R (2R,3R)-(+)-bis(diphenylphosphino)butane
View our on-demand webinar: The Cornerstone of Synthesis for Pharmaceutical Applications
Phosphine Ligands for Flavors and Fragrances
Phosphine ligands are essential raw materials for the preparation of synthetic flavors and fragrances. Our specialty phosphorus chemistry enables access to desired chemicals in a more sustainable manner than by isolating them from natural sources. In some cases, only one “form” of a chemical carries the odor or flavor desired; enantioselective catalysis can isolate the targeted “form.” Syensqo develops chiral phosphine ligands and other solutions well-suited for a range of flavor and fragrance applications.
Key Products:
- RhodaPhos® CP100R (2R,3R)-(+)-bis(diphenylphosphino)butane
- (R,R) Methyl Duphos (1,2-bis[(2R, 5R)-2,5 dimethyl (phospholano)] benzene)
Phosphine Ligands for Agrochemicals
Syensqo designs ligands and precursors for the development of AIs and other agrochemicals. Working directly with the end-user or catalyst producer, our phosphine ligands can be tailored to a particular catalytic transformation. Our alkyl phosphines that are leveraged in agrochemicals enable the synthesis of the desired AI to either help crop development or mitigate harmful pests. These phosphine ligands are widely utilized in agrochemical reactions such as cross-coupling, chiral hydrogenation and chiral coupling. Additionally, our phosphine ligands for homogeneous catalysis in the AI market are compliant with today’s stringent requirements and backed by Syensqo’s regulatory and toxicology support.
Key Products:
- RhodaPhos® CP100R (2R,3R)-(+)-bis(diphenylphosphino)butane
- CYTOP® 186 (diphenylphosphine)
- (R,R) Methyl Duphos (1,2-bis[(2R, 5R)-2,5 dimethyl (phospholano)] benzene)
Phosphine Ligands for Fine Chemicals
Syensqo specializes in the development of phosphine ligands for the fine chemicals industry, often working in partnership with catalyst producers and manufacturers. With a unique and diverse selection of phosphorus reagents and derivatives, our ligands are an essential building block for the manufacture of fine chemicals, such as detergent alcohols, at scale. Syensqo’s phosphine ligands exhibit best-in-class selectivity and efficiency, and are well-suited for reactions such as hydrogenation, metathesis and hydroformylation.
Key Products:
- RhodaPhos® NiCat Dichlorobis(tributylphosphine)nickel(II)
- CYTOP® 282T 9-phosphabicylononane
- CYTOP® 341 (triisobutylphosphine)
- CYTOP® 320 (triethylphosphine)
Phosphine Ligands for Plastics and Other Polymers
Syensqo is an industry leader in the development of phosphine ligands for the production of plastics and other polymers used in a myriad of industrial applications. We offer significant capacity to support manufacturing at virtually any scale. With exceptional diversity of structure, tunability and thermal stability, Syensqo’s polymerization experts deliver the optimal phosphine ligand for a range of reactions and applications such as oligomerization, polyethylene production, polypropylene production, monomer production and cross-coupling.
Key Products:
