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Understanding Ceramides

Understanding Ceramides

Enhancing Skin Structure for Timeless Beauty

The Power of Ceramides in Beauty Care

The skin is our body's largest organ and serves as a critical barrier and sensory interface with the environment. It's composed of three layers: the protective outer layer (epidermis), the supportive middle layer (dermis), and the deeper layer for insulation and energy storage (hypodermis).

 

The Key Role of the Stratum Corneum

Structure of the stratum Corneum

The stratum corneum, or the top part of the epidermis, resembling a “brick wall” structure, consists of corneocytes (dead keratinocytes) and a lipid matrix that includes ceramides, cholesterol, and fatty acids. Ceramides play a vital role as the “cement” holding the “bricks” together, crucial for maintaining the skin's barrier integrity and hydration.

The stratum corneum is essential for skin health and has two main roles: locking moisture inside and protecting from external aggressions. 

Cells organization and its impact on the barrier function

What Are Ceramides?

Ceramides are a type of waxy lipid molecules that result from the reaction of a sphingosine with a fatty acid via an amide bound. They are amphiphilic structures composed of a polar head and an apolar tail. Ceramides are naturally present in high concentrations within the cell membrane of keratinocytes, then theses molecules play a crucial role in maintaining the barrier function and retaining moisture in the upper layers of the epidermis.

Chemical structure of Ceramides


The different types of Ceramides 

 The different types of Ceramides

The Role of Ceramides in Preserving Skin Integrity

Ceramides are pivotal in maintaining the skin’s integrity, acting as a protective barrier in the stratum corneum to lock in moisture and shield against environmental damage. With aging and with time, cell renewal slows down, and the natural level of ceramide inside the skin declines. When ceramide levels are low, the skin becomes dry, dull, less protected and prone to the first signs of aging. Replenishing these essential lipids can restore the skin's hydration, elasticity, and overall appearance, effectively combating transepidermal water loss and protecting skin integrity.

Skin: normal versus disrupted lamellar structure

Restoring Skin with Ceramides

Ceramides are fundamental for healthy skin, crucial for its barrier function and moisture retention. They contribute to structured skin by:

  • Replenishing the Skin Barrier: Ceramides, the essential lipids or 'glue' of our cells, are critical in keeping the skin barrier healthy and intact. They fortify the stratum corneum structure by ensuring the skin cells are tightly held together, maintaining a robust barrier.
  • Protecting the Skin: By bolstering the skin barrier, ceramides play a vital role in shielding the skin from external stressors such as pollutants, UVs, and free radicals. This protection is key in preventing skin conditions and maintaining skin integrity avoiding premature aging.
  • Maintaining Barrier Homeostasis: The balance between the transformation of keratinocytes to corneocytes and their natural shedding is crucial for skin integrity. Ceramides, along with cholesterol and free fatty acids, are fundamental in maintaining this balance, supporting the skin's natural renewal processes and immune functions.
  • Enhancing Skin Appearance: Ceramides help combat dehydration-related issues like dryness, flakiness, and the appearance of fine lines by replenishing lost lipids. This restoration improves the skin's softness and smoothness, enhancing its overall appearance and radiance.
  • Locking in Moisture: With time, or certain skin conditions can lead to a decrease in natural ceramide levels, compromising the skin barrier and leading to moisture loss. Supplementing with ceramides helps lock in moisture, keeping the skin hydrated and healthy.

Two Ways to Boost the Skin 

While ceramides are inherently present in the skin, their levels can diminish due to various factors like aging, skin conditions such as eczema and psoriasis, sun exposure or environmental aggressions, leading to compromised barrier function and dry skin. 

Two primary methods are employed to counter this loss or degradation: 

  1. boosting the skin's natural ceramide synthesis through active ingredients that stimulate the skin's biological mechanisms 

  2. supplementing the skin directly with ceramide-containing skin care products. These supplemental ceramides need to be "biomimetic," meaning they replicate the skin's natural ceramides, thereby restoring the skin barrier and improving moisture retention effectively.

At Syensqo, we recognize the importance of ceramides in healthy skin care routines but also for beauty in general. Our newly launched Cerafy™ range leverages the power of ceramides to enhance skin's natural defenses, ensuring it remains hydrated, plump, and youthful-looking. Cerafy™ can be also used in hair care routines.